Studies on the salivary gland hormones labeled with I 131. 3. Effect of ligation of several blood vessels on the degradation and distribution of I 131-labeled parotin in vivo.

Previously it was reported that large localization of radioactivity was found in liver, kidney and spleen following the intravenous injection of I 131-labeled Parotin to rats(Tanaka and Ito,1958). And subsequently it was also observed that the rate of degradation of I 131-labeled Parotin in vivo was remarkably decreased by the simultaneous injection of intact Parotin with the labeled Parotin to rats (Tanaka et al., 1958). As simple hepatectomy causes a strong congestion in spleen,pancreas,and mesenteries, various modified methods have been reported including the functional evisceration by Russell(1942), the evisceration by Ingle et al.(1947)and physiological hepatectomy by Elgee and Williams(1954). It was reported that nephrectomy or physiological hapatectomy decreased the rate of degradation of I 131labeled insulin in rats(Elgee et al., 1953; Elgee and Williams, 1954). The present report deals with the effect of ligation of several blood vessels on the degradation and distribution of I 131-labeled Parotin in rats.